HIV - 2 – an EnIGMa !

The Luteal Phase after GnRHa Trigger-Understanding An Enigma

HTLV-I Infection in the Tropics a Natural Model of Disease

Introduction The discovery in 1980 of the first human retrovirus (1), the human T-lymphotropic virus type 1 (HTLV-I), inaugurated a new era in human pathology. Two conditions were promptly associated with this retroviral infection (2): adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis (TSP). Thus, this discovery solved a longlasting enigma in tropical medicine, the cause of...

HIV-1 Fitness: Implications for Drug Resistance, Disease Progression, and Global Epidemic Evolution

In the past five years, the HIV research field has shown renewed interest in the replicative capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex vivo viral fitness on population size (viral load), drug resistance, and disease progression. For example, studies on HIV-1 fitness of drug-resistant mutants under different selective pressures have led to a better...

HIV, TB and ART: the CD4 enigma

1 This is a development of a presentation given by Brian Williams at the ‘Modelling and Quantitative Research Priorities’ meeting of the TB Modelling and Analysis Consortium (TB MAC), funded by the Bill and Melinda Gates Foundation, 28th and 29th September 2012, Johannesburg, South Africa Abstract The concentration of CD4+ T-lymphocytes (CD4 count) in a person’s plasma is widely used to decide ...

Giant pyogenic granuloma of the thigh: a case report

INTRODUCTION Pyogenic granuloma or lobular capillary hemangioma remains an etiopathological enigma, with trauma, inflammatory and infectious agents being the commonest suspected causative agents. These lesions affect mucous membranes of the upper aero-digestive tract, and skin. HIV patients diagnosed with pyogenic granuloma present with multiple lesions, caused by Bartonella spp. CASE PRESENT...